Diclofenac WikipediaDiclo redirects here. For the organic solvent sometimes called Di clo, see Dichloromethane. Diclofenac. Clinical data. Trade names. Cataflam, Voltaren, see trade names1AHFSDrugs. Monograph. Medline. Plusa. 68. 90. 02. Pregnancycategory. AU CUS C Risk not ruled out in 1st and 2nd trimester, D in 3rd trimester. Routes ofadministrationoral, rectal, intramuscular, intravenous renal and gallstones, topical. ATC code. Legal status. Legal status. AU S2 Pharmacy only S4. UK POM Prescription only P for topical formulation only in most preparationscountries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures. Pharmacokinetic data. Protein binding. More than 9. Metabolismhepatic, oxidative, primarily by CYP2. C9, also by CYP2. C8, CYP3. A4, as well as conjugative by glucuronidation UGT2. B7 and sulfation 2 no active metabolites exist. Biological half life. Tabtight professional, free when you need it, VPN service. Top Games The Gate of Firmament N. P. P. D. RUSH The milk of Ultraviolet the Sequence n Verlore Verstand v1. Sora no. RebelMouse is the best CMS 2017 and 1 Wordpress VIP alternative. See what makes us so fast, and why you should replatform with us today. Excretion. 40 biliary 6. Identifiers2 2,6 Dichloroanilinophenylacetic acid. CAS Number. Pub. Chem. CIDIUPHARBPSDrug. Painkiller No Cd Patch' title='Painkiller No Cd Patch' />Bank. Chem. Spider. UNIIKEGGCh. EBICh. EMBLPDBligand. Labelflash Software Vista. ECHA Info. Card. 10. Chemical and physical data. Formula. C1. 4H1. Painkiller No Cd Patch' title='Painkiller No Cd Patch' />Cl. NO2. Molar mass. D model JSmolOCOCc. Antivirus Quick Heal there. Nc. 2cClcccc. 2Cl. In. Ch. I1. SC1. H1. Cl. 2NO2c. 15 1. H,8. H2,H,1. 8,1. YKey DCOPUUMXTXDBNB UHFFFAOYSA N Y NY what is this verifyDiclofenac sold under a number of trade names1 is a nonsteroidal anti inflammatory drug NSAID taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names. The name diclofenac derives from its chemical name 2 2,6 dichloranilino phenylacetic acid. Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister and introduced as Voltaren by Ciba Geigy now Novartis in 1. In the United Kingdom, United States, India, and Brazil diclofenac may be supplied as either the sodium or potassiumsalt in China, it is most often supplied as the sodium salt, while in some other countries it is only available as the potassium salt. It is available as a generic drug in a number of formulations, including diclofenac diethylamine, which is applied topically. Over the counter OTC use is approved in some countries for minor aches and pains and fever associated with common infections. As of 2. 01. 5 the cost for a typical month of medication in the United States is 5. USD. In European countries, the cost is no more than 8. US for 2. 4 weeks use. The drugs use in animals is controversial due to its toxicity which can rapidly kill scavenging birds that eat dead animals. It has been banned for veterinary use in many countries. Medical useseditDiclofenac is used to treat pain, inflammatory disorders, and dysmenorrhea. Inflammatory disorders may include musculoskeletal complaints, especially arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, dental pain, temporomandibular joint TMJ pain, spondylarthritis, ankylosing spondylitis, gout attacks,6 and pain management in cases of kidney stones and gallstones. An additional indication is the treatment of acute migraines. Diclofenac is used commonly to treat mild to moderate postoperative or post traumatic pain, in particular when inflammation is also present,6 and is effective against menstrual pain and endometriosis. Prime Suspect A Price To Pay. Diclofenac is also available in topical forms and has been found to be useful for osteoarthritis but not other types of long term musculoskeletal pain. It may also help with actinic keratosis, and acute pain caused by minor strains, sprains, and contusions bruises. In many countries,1. Diclofenac eye drops have also been used to manage pain for traumatic corneal abrasion. Diclofenac is often used to treat chronic pain associated with cancer, in particular if inflammation is also present Step I of the World Health Organization WHO scheme for treatment of chronic pain. Diclofenac can be combined with opioids if needed such as a fixed combination of diclofenac and codeine. Dyloject diclofenac 2 ml for IV and IM administration. ContraindicationseditHypersensitivity against diclofenac. History of allergic reactions bronchospasm, shock, rhinitis, urticaria following the use of other NSAIDs such as aspirin. Third trimester pregnancy. Active stomach andor duodenal ulceration or gastrointestinal bleeding. Inflammatory bowel disease such as Crohns disease or ulcerative colitis. Severe insufficiency of the heart NYHA IIIIVPain management in the setting of coronary artery bypass graft CABG surgery. Severe liver insufficiency Child Pugh Class CSevere renal insufficiency creatinine clearance lt 3. Caution in patients with pre existing hepatic porphyria, as diclofenac may trigger attacks. Caution in patients with severe, active bleeding such as cerebral hemorrhage. NSAIDs in general should be avoided during dengue fever, as it induces often severe capillary leakage and subsequent heart failure. Caution in patients with fluid retention or heart failure. Can lead to onset of new hypertension or worsening of pre existing hypertension. Can cause serious skin adverse events such as exfoliative dermatitis, Stevens Johnson Syndrome SJS, and toxic epidermal necrolysis TEN, which can be fatal2Diclofenac consumption has been associated with significantly increased vascular and coronary risk in a study including coxib, diclofenac, ibuprofen and naproxen. Upper gastrointestinal complications were also reported. Major vascular events were increased by about a third by diclofenac, chiefly due to an increase in major coronary events. Compared with placebo, of 1. Vascular death was increased significantly by diclofenac. CardiaceditIn 2. UK Medical Research Council and the British Heart Foundations, and collaboration coordinated by the Clinical Trial Service Unit Epidemiological Studies Unit CTSU at the University of Oxford, UK major vascular events were increased by about a third by diclofenac rate ratio 14. CI 11. 217. 8 p00. Compared with placebo, of 1. Vascular death was increased significantly by diclofenac 16. Following the identification of increased risks of heart attacks with the selective COX 2 inhibitorrofecoxib in 2. NSAIDs group, including diclofenac. Research results are mixed, with a meta analysis of papers and reports up to April 2. Professor Peter Weissberg, Medical Director of the British Heart Foundation said, However, the increased risk is small, and many patients with chronic debilitating pain may well feel that this small risk is worth taking to relieve their symptoms. Only aspirin was found not to increase the risk of heart disease however, this is known to have a higher rate of gastric ulceration than diclofenac. A subsequent large study of 7. NSAIDs or coxibs found no additional cardiovascular risk from diclofenac use. A very large study of 1,0. Danish users of various NSAIDs or coxibs found the Use of the nonselective NSAID diclofenac and the selective cyclooxygenase 2 inhibitor rofecoxib was associated with an increased risk of cardiovascular death odds ratio, 1. In Britain the Medicines and Healthcare Products Regulatory Agency MHRA said in June 2. As of January 1. 5, 2.
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